GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1926657 | 1 | rs6492769 | chr13:95870022 | ABCC4 | chr13:95672084-95953687:- | -0.18 | -3.56 | 0.000409 | Breast cancer |
| THCA | cis | rs2412459 | 1 | rs6492925 | chr15:40304170 | SRP14 | chr15:40327891-40331389:- | -0.2 | -3.86 | 0.000128 | Response to haloperidol in psychosis |
| THCA | cis | rs6493858 | 1 | rs6493858 | chr15:56736478 | TEX9 | chr15:56657644-56738071:+ | 0.3 | 7.53 | 2.62E-13 | Relative hand skill in reading disability |
| THCA | cis | rs6494537 | 1 | rs6494521 | chr15:65739928 | DPP8 | chr15:65737999-65810035:- | -0.09 | -3.95 | 8.88E-5 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs6494521 | chr15:65739928 | SLC24A1 | chr15:65903704-65953256:+ | -0.16 | -3.86 | 0.00013 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs6494528 | chr15:65865632 | DPP8 | chr15:65737999-65810035:- | -0.09 | -3.94 | 9.34E-5 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs6494528 | chr15:65865632 | SLC24A1 | chr15:65903704-65953256:+ | -0.16 | -3.92 | 0.000103 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs6494529 | chr15:65902922 | DPP8 | chr15:65737999-65810035:- | -0.1 | -4.13 | 4.24E-5 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs6494529 | chr15:65902922 | SLC24A1 | chr15:65903704-65953256:+ | -0.16 | -3.95 | 8.94E-5 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs6494532 | chr15:65975798 | DPP8 | chr15:65737999-65810035:- | -0.09 | -3.8 | 0.000167 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs6494532 | chr15:65975798 | SLC24A1 | chr15:65903704-65953256:+ | -0.16 | -3.82 | 0.000153 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs6494537 | chr15:66051345 | DPP8 | chr15:65737999-65810035:- | -0.1 | -4.13 | 4.31E-5 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs6494537 | chr15:66051345 | SLC24A1 | chr15:65903704-65953256:+ | -0.15 | -3.67 | 0.000275 | Mean corpuscular hemoglobin |
| THCA | cis | rs2404602 | 1 | rs6495206 | chr15:76870963 | SCAPER | chr15:76640529-77197744:- | -0.16 | -5.23 | 2.55E-7 | Blood metabolite levels |
| THCA | cis | rs2028299 | 1 | rs6496609 | chr15:90379632 | AP3S2 | chr15:90373832-90456222:- | -0.77 | -19.51 | 9.17E-63 | Type 2 diabetes |